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Objective evaluation of cognitive brain function and dysfunction

Objective

The COBRAIN research project will develop standardized noninvasive tests of human cognitive brain functions in health and in different common neuromental diseases and pathological conditions.

The tests will enable objective neurophysiological evaluation of central auditory processing, sensory memory, and attention, which deteriorate in various forms of neuromental disorder.

The COBRAIN project will utilize modern functional brain imaging methods and recent major findings of cognitive electrophysiology and magnetoencephalography (MEG) in order to develop standardized tests of cognitive brain function and dysfunction. These tests will permit objective neurophysiological evaluation of central auditory processing, sensory memory, and attention, which deteriorate in various forms of neuromental disorder. The large-scale clinical application of these tests is made possible by recent advances in cognitive electrophysiology and brain imaging technologies that have recently opened a completely new window to brain functions. In particular, COBRAIN will make use of the mismatch negativity (MMN) and its MEG equivalent MMNm which are manifestations of the brain's automatic response to any suprathreshold change in a repetitive sound. These new non-invasive tests will be adjusted for clinical evaluation and monitoring of patients with different types of major neuromental disorders. They will also be fine-tuned for measuring cognitive brain dysfunction in patients with cerebral lesions and in chronic alcoholics, both major concerns for the European healthcare systems. In addition, COBRAIN will try to develop MMN-based non-invasive methods for determining the malfunctioning hemisphere in temporal-lobe epilepsy. A breakthrough has already been made in using MMN for predicting the recovery of consciousness in coma patients. This line of MMN application will be developed further in COBRAIN.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

University of Helsinki
Address
13,P.o.b
00014 Helsinki
Finland

Participants (6)

Burden Neurological Institute
United Kingdom
Address
Stoke Lane
BS16 1QT Stapleton Bristol
Hebrew University of Jerusalem The Authority for Research and Development
Israel
Address
Hebrew University Of Jerusalem
91905 Jerusalem
Helsinki University Central Hospital
Finland
Address
508,P.o.b.
00029 Hyks
Institut National de la Santé et de la Recherche Médicale
France
Address
151,Cours Albert Thomas
69003 Lyon
Ludwig-Maximilians-Universität München
Germany
Address
13,Leopoldsstrasse
80802 Muenchen
Universitat de Barcelona
Spain
Address
171,Passeig De La Vall D'hebron
08035 Barcelona