Objective
The Concertation aims to co-ordinate and facilitate investigations into the basic mechanisms controlling vascular synthesis of nitric oxide (NO) as well as the alterations in NO production associated with the development of such cardiovascular diseases as arteriosclerosis, hypertension, restenosis, ischaemia and diabetes.
To this end, the Concertation will utilise a variety of different methods and approaches from the fields of cellular physiology, biochemistry, cardiovascular pharmacology, molecular biology and clinical cardiology. Research work will be carried out on a multicenter basis involving eight research teams from six different European countries supplemented by five associated cardiology or cardiovascular surgery units. Any leads for drug development, improved therapy or diagnosis arising from the Concertation will be further tested in animal models and, where applicable, also in patients. At present, the following research tasks have been selected:
- Generation of knockout mice for the inducible NO synthase and establishment of in vivo disease models.
- Role of tetrahydrobiopterin supply for inducible NO synthase activity.
- Role of NO in the pathogenesis of diabetic vasculopathy.
- Basic mechanisms regulating the rate of apoptotic cell death in relation to the role of NO in inflammatory cardiovascular diseases.
- Cellular and biochemical mechanisms involved in 'ischemic preconditioning' - Role of kinin-mediated NO release and NO synthase induction.
- Analysis of the potential protective effect of isoenzyme-specific NO synthase inhibitors in cardiovascular inflammation.
- Molecular and cellular mechanisms involved in the regulation of inducible NO synthase expression at the transcriptional and post-transcriptional level.
- Regulation of cyclooxygenase II expression by cytokines.
- Molecular mechanisms of shear stress-dependent endothelial NO synthase expression.
- Role of the redox state, anti-oxidants and NO in the expression of pro- atherosclerotic gene products.
- Role of a dysfunctional endothelium in the development and manifestation of hypertension.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
60590 FRANKFURT AM MAIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.