Objective
The major focus of this study will be to collect families with (a) three or more prostatic cancer cases diagnosed at any age; or (b) two or more affected brothers diagnosed before the age of 65 years. Such families are candidates for carrying an inherited susceptibility predisposing to prostatic and possibly other malignancies. The families will be collected through major clinical urology centres through Europe. This bank of material, both DNA and RNA, will then be available for molecular genetic studies to identify genes predisposing to prostate cancer. The project will initially use genetic linkage analysis to identify genes which contribute to the risk of prostate cancer and to assess the importance of this gene/these genes to familial prostate cancer. DNA markers which are usually based on microsatellite repeats and which are known to have high degrees of polymorphism are typed within the families and tested for co-segregation with the putative prostate cancer susceptibility gene. Evidence for co-segregation is assessed statistically. The analysis will focus on a variety of candidate genes which are known to play a role in either prostate development or in other cancer susceptibility syndromes such as those for the breast cancer syndromes, BRCA1 and BRCA2. Only in the event that none of these turn out to be important would a genome-wide mapping search be initiated. When a gene or more probably a genetic region is identified as being important, we will assess the importance of this region to familial prostate cancer.
The other approach will be to examine the importance of genes thought to modify the risk of prostate cancer using a case-control approach. We will collaborate with ongoing studies which are investigating environmental causes of prostate cancer to examine the role of gene-environment interactions in determining prostate cancer susceptibility.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine urology
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LS9 7TF Leeds
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.