Objective
To investigate the influence of cell permeability and drug efflux systems on drug susceptibility
To identify the resistance mechanisms to streptomycin and clarithromycin
To study the mode of action of isoniazid
To characterise the cellular function of aminoglycoside acetyltransferase genes and their role in aminoglycoside inactivation
To search for a potential mdr gene in M.tuberculosis
Characterisation of drug resistance mechanisms at a genetic and biochemical level is a prerequisite for design and development of new drugs endowed with a high degree of selectivity that will prevent or curtail the spread of resistance conferring mutations. Implementation of new technology for rapid recognition of drug resistance will result in early initiation of effective chemotherapy as well as in preventing further transmission.
The project focuses at several aspects of mycobacterial drug resistance: acquired resistance to first-line drugs; mechanisms of the high inherent drug resistance; role and function of chromosomally encoded acetyltransferases; investigation of drug combination effects; multi-drug resistance genes. The project uses a multidisciplinary approach targeting resistance mechanisms at several levels, e. g. cell wall permeability, drug efflux, drug modifying enzymes and identification of intracellular targets of drugs. The project will allow the mechanisms of drug action and drug resistance to be elucidated both at the genetic and biochemical level.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
30625 HANNOVER
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.