Objective
- To maintain a European facility for the production of transgenic models of cardiovascular disease.
- To provide access to the facility and its materials to participating laboratories for the investigation of gene regulation and function, with specific focus on those genes involved in cardiovascular homeostasis.
The technology for introducing genes into the mammalian germline is widely used in many areas of modern biomedical research. The 'Transgeneur' programme has been running for 5 years and consists of a dual-centre central facility which provides optimal flexibility for collaborative projects and for overcoming technical difficulties. This programme supports a central facility to service the needs of European researchers actively engaged in, or wishing to engage in, the application of transgenic techniques to the understanding of cardiovascular disease, in particular hypertension. Through studies on the regulation of the genes involved in blood pressure homeostasis, it is expected that greater insights into the underlying mechanisms surrounding both normal and abnormal blood pressure control will be obtained.
Whilst numerous laboratories routinely generate transgenic mice, the transgeneur programme provides one of the few facilities able to consistently generate transgenic rats. The flexibility to utilise both species enables researchers to more effectively design their studies. Due the expense and time involved in the production of transgenic animals, access to such facilities is severely limited for European research groups working on cardiovascular disease. Through the production and dissemination of transgenic strains the programme aims to enhance the efforts of individual laboratories both in the study of gene regulation and the development of disease models.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH9 3JQ EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.