Objective
- To collate information on the rare metabolic myopathies
- To establish an Internet presence for ready access to this data
- To provide a forum for exchange of ideas and methodologies
- To provide access to DNA probes and primers for study of these conditions
CARMEN will direct attention to a group of rare muscle diseases that arise from defects in the enzymes of muscle energy metabolism. The common feature of these diseases is that disruption of the mechanisms that deliver energy to the contractile apparatus leads to an exercise intolerance and rhabdomyolysis. The similarities in clinical presentation can cause complications in diagnosis, but implies that there may be some common strategies for treatment or therapy. CARMEN will gather information on these patients through a novel database, maintained on a central server and accessed through the Internet by any member of the CARMEN (http://carmen.bi.umist.ac.uk(opens in new window)). The database will also be used to disseminate new technologies and inform about developments. In addition, workshops and short-term study exchanges will be used to develop methodological capabilities and act as a focus for new pan-European collaborations on these conditions. The pooled patient information, coupled with shared capabilities and skills, will accelerate and give added dimensions to research in this group of myopathies. Access to diagnostic probes, antibodies and primers will facilitate molecular diagnosis. Studies arising from CARMEN will benefit from the critical mass of subjects that is sufficiently large to be informative but which in addition, may identify additional factors that contribute to clinical heterogeneity. The CARMEN partners are recognised as centres of excellence with considerable experience in these myopathies. However, CARMEN is structured in such a way that it will grow rapidly and encourage interaction by any centre in Europe that shares our interest. The use of the Internet as the main communication vehicle in CARMEN offers an immediacy of interaction with the data sources that cannot be realised through conventional means of communication. As such, CARMEN is a model for a new mode of sharing of information and expertise that will demonstrate the potential for this type of electronic networking.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences internet
- natural sciences computer and information sciences databases
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Coordinator
M60 1QD Manchester
United Kingdom
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