Objective
- To provide a network between major centres across Europe to generate and exchange knowledge and information about severe asthma.
- To enable comparisons to be made between the type, pattern, magnitude and underlying causes of severe asthma in each Member State by contributing patients to a single protocol.
- To analyse clinical and laboratory material as surrogate markers of airway inflammation and apply direct assessment of airway inflammation by bronchial biopsy and lavage.
- To investigate the natural history of severe asthma with a view to long term follow up.
We propose to establish a European Network to draw together expertise from some of the leading asthma research groups. To achieve our objectives we wish to work to a common protocol in which severe asthma defined by recurrent hospital admissions will be compared to a "control group" with less severe disease. Partners will contribute 20 patients into each group identified on the basis of hospital records. In accordance with the facilities available, each partner will contribute clinical, physiological and biological fluids and tissue/cell samples to a laboratory with specific expertise. In the first phase a detailed questionnaire including life quality assessment and measurement of pulmonary function and bronchial responsiveness will be undertaken. Biomarkers of airway inflammation will be measured including bronchial mucosal biopsy, analysis of blood, induced sputum and urine for inflammatory cell markers, PCR-based virus identification, assessment of allergic status and exposure to indoor and outdoor air pollutants. The second phase will consist of a longitudinal follow-up with assessment during exacerbations and at regular six monthly intervals at which time clinical, physiological and non-invasive biomarkers will be measured in order to describe the natural history of severe asthma.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- humanities history and archaeology history
- natural sciences biological sciences microbiology virology
- engineering and technology environmental engineering air pollution engineering
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Coordinator
SO9 4XY Southampton
United Kingdom
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