Objective
Mantle lymphomas (MCL) represent a recently recognised sub-type of malignant lymphomas which are charaterised by a specific histology and immunophenotype and an unfavourable clinical course. Hence, response to chemotherapy is poor and patients with this disease usually face a median survival of less than three years. The recent discovery that MCL are associated with a specific chromosomal abnormality, the translocation t (11;14) that leads to the deregulation of cyclin D 1 and over-expression of bcl 1 and a consecutive impairment of cell cycle control has opened new perspectives to better understand the biology of this lymphoma and also potentially its clinical course. The current multinational study aims at gaining new insights into the biology of MCL and its appropriate clinical management and tries to explore a novel therapeutic strategy comprising myeloablative radio-chemotherapy with subsequent peripheral blood stem cell transplantation. These objectives are addressed in three major steps :
- The assessment of clinical and histopathologic features of presentation as obtained from a retrospective analysis of patients that have been treated with conventional therapies at the participating institutions;
- The biologic characterisation of MCL by means of modern immunophenotypic and molecular techniques;
- The prospective evaluation of myeloablative radio-chemotherapy with subsequent blood stem cell transplantation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine transplantation
- natural sciences biological sciences histology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
37075 Göttingen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.