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Immune diagnosis of dirofilariasis infections in humans and animal reservoirs, and protection in animals

Objective



Dirofilariasis is a parasitic zoonosis caused by Dorofilaria immitis, a nematode belonging to the family Onchocercidae. This parasitosis affects dogs and cats which act as reservoirs, and occasionally humans in whom it could originate benign pulmonary nodules that can be mistaken for pulmonary carcinoma. Dirofilariasis is a public health problem and its control requires diagnostic and protective measures. Because products of this nature do not exist in the market, the constitution of a European industrial/university team for their production would constitute a great opportunity for pre-empting the American industry in this field. The objectives of the proposal are: Identification of antigens of diagnostic/protective interest. 2. Cloning genes related to these antigens. 3. To probe the diagnostic/protective capacity of the recombinant antigens. This research has a pre-competitive character and its objectives are in accordance with those of the BIOMED Programme. An important technical advantage can be achieved if these products are manufactured, because: they will occupy an unexploited space in the market , the improvement of the current methods could be achieved and they will contribute to the improvement and reduction in costs of the health services. The selected tasks for the exploratory phase are related to the development of the proposal (the search for new partners; verification of the originality of the research and the evaluation of the economic impact), and to the study of the viability of the proposal (identification of polypeptides of interest and genes related to them in a cDNA expression library of D. immitis).

Funding Scheme

EAW - Exploratory awards

Coordinator

Laboratorio Farmacéutico LOFARMA SpA
Address
Viale Cassala
20143 Milano
Italy

Participants (3)

Medicamentos y Premezclas SL
Spain
Address
Km 256,Carretera Burgos
37448 Calzada De Don Diego
UNIVERSITY OF SALAMANCA
Spain
Address
S/n,avda. Del Campo Charro S/n
37007 Salamanca
Universitá degli Studi di Milano
Italy
Address
Via Celoria
20133 Milano