Objective
The main objective of this project is to gather several teams with complementary expertise to produce and evaluate new attenuated strains of M. tuberculosis as vaccine candidates. This project includes teams from 5 different European countries (France, Great Britain, Denmark, Belgium, and Spain) and an industrial partner (Pasteur Mérieux Serums et Vaccins) who has extensive expertise in the development of vaccines. We propose to generate attenuated strains of M. tuberculosis by disrupting genes involved in the pathogenesis capacity. Some potential targets for gene disruption have already been identified and will be deleted by allelic exchange. Other target will be identified either by random transposon mutagenesis or by homology with virulence genes of other bacteria. Induction of protection by attenuated M. tuberculosis strains will be evaluated in mouse and guinea pig models and compared with protection conferred by BCG. This project has been made possible by the construction of genetic and immunologic tools as a result of previous collaborative studies between the different teams and by the availability of sequences coming from the ongoing TB genome project. These tools will be further developed during the course of this project. They should be valuable for many other studies on mycobacteria, including the search for new diagnostic reagents and new
efficient drugs against M. tuberculosis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75724 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.