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Flourescence imaging for detection, localisation and stageing of superficial cancer in the female lower genital tract

Objective

-To contribute to the development of cost effective minimally invasive diagnostic procedures based on optical imaging techniques.
-To investigate different fluorescence measurement techniques developed by the partners for early detection, localisation, staging and screening of primary cancers and premalignancies in the cervix, the vagina, the vulva, the endometrium and of metastatic ovarian cancer.
- To develop clinical prototypes for fluorescence colposcopy, fluorescence hysteroscopy and fluorescence laparoscopy.
-To perform clinical pilot experiments with these prototypes.

The performance of five different basic approaches to fluorescence diagnostics that currently exist in five of the partner research institutes will be for early detection, localisation, staging and screening of primary cancers and pre-malignancies in the cervix, the vagina, the vulva, the endometrium and of metastatic ovarian cancer. These techniques are based on the fluorescence of exogenous or endogenous dyes: Imaging of the fluorescence intensity of tumour localising drugs; Double ratio fluorescence imaging; Imaging of the fluorescence of pH sensitive dyes; Fluorescence decay time imaging; and Fluorescence spectroscopy. These five different techniques each focus on a different aspect of the interaction between the dye, the light and the tissue. Possible combinations between the different techniques will be investigated and an optimum approach with respect to effectiveness and cost will be developed, tested and clinically investigated. Three main areas of visual diagnostic imaging are presently available and are practised as routine diagnostic techniques in clinical gynaecology: colposcopic imaging of the cervix, the vagina and the vulva; hysteroscopic imaging of the endocervix and the uterus and laparoscopic imaging of the ovaries and the abdominal cavities. The present project will closely follow this approach and aim to develop:
1) A fluorescence colposcopy system for detection of cancer and precancer of the cervix (CIN), the vulva (VIN) and the vagina (VAIN).
2) A fluorescence hysteroscopy system for detection of cancer and precancer of the endocervix and of precancer (endometriosis) and cancer (adenocarcinoma, adenoacanthoma) of the uterus.
3) A fluorescence laparoscopy system for detection of cancer of the ovaries and metastatic disease in the abdominal cavity.

These clinical prototypes to be developed will employ state-of-the-art optical technology and image processing techniques and will be evaluated clinically. Although the present proposal is focused at gynaecological cancers, the technology developed will have a much broader applicability, it may have a significant impact on cancer management in general and is thus of utmost importance to the European industry.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
9,Meibergdreef 9
1105 AZ Amsterdam
Netherlands

Participants (8)

Academisch Ziekenhuis Rotterdam
Netherlands
Address

3008 AE Rotterdam
Institut National Polytechnique de Toulouse
France
Address
2,Rue Camichel
31071 Toulouse
Institut National de la Santé et de la Recherche Médicale
France
Address
Place De Verdun
59037 Lille
Karl Storz GmbH & Co
Germany
Address
8,Mittelstrasse
78532 Tuttlingen
Ludwig-Maximilians-Universität München
Germany
Address
23,Marchioninistraße 23
81377 München
Nederlands Kanker Instituut
Netherlands
Address
121,Plesmanlaan 121
1066 CX Amsterdam
SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE
Switzerland
Address
Enac-lpas
1015 Lausanne
Université d'Auvergne - Clermont-Ferrand 1
France
Address
13,Boulevard Charles De Gaulle 13
63033 Clermont-ferrand