Objective
The overall objective of this project is to test the hypothesis that cell death in the central nervous system is critically dependent on the balance between pro-inflammatory cytokines such as interleukin-1, and anti-inflammatory cytokines such as the interleukin-1 receptor antagonist, interleukin-4, interleukin-10 and interleukin-13.
For this purpose, the participating laboratories will :
assess whether experimental insults which lead to brain damage modify the brain expression of anti-inflammatory cytokines in a regional and temporal manner;
determine the contribution of these anti-inflammatory cytokines to brain insults, by experimentally modifying expression and action of these molecules in well defined model systems;
investigate the way anti-inflammatory cytokines interfere with the synthesis and actions of interleukin-1 in the brain.
Using standardized reagents produced by a Centralized Facility, the participants will study the expression and action of anti-inflammatory cytokines in several animal models of brain inflammation, which differ by the severity, time course and cell types responsible for the local production of these molecules (brain resident cells or invading blood cells). These animal models include a model of acute non-immune brain inflammation (systemic administration of lipopolysaccharide), a model of acute brain trauma (lateral fluid percussion on the cortex), a model of chronic non-immune-mediated neurodegeneration (cerebellar mutant mice), and a model of chronic immune-mediated brain inflammation (the delayed-type hypersensitivity response to bacillus Calmette Guerin). For each of these models, standard animals and transgenic animals with an overexpression or a decreased expression of anti-inflammatory cytokines will be used. The investigation of the mechanisms of action of anti-inflammatory cytokines on the expression and action of pro-inflammatory cytokines will be carried out in vitro, using primary cultures of neurones, astrocytes and microglia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
33077 Bordeaux
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.