Objective
The major objectives of this research project are to develop new and improve hyphenated techniques (e.g. LC-NMR-MS, CE-NMR-MS, CE-MS-MS) for the use in
- investigation of reactive drug metabolites (drug allergy)
- investigation of plasma proteins (diagnostic tool)
The overall aim of the proposed RTD project is to further develop and apply hyphenated methods involving separation techniques [high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE)] and nuclear magnetic resonance (NMR) and mass spectrometry (MS) for the study of i) reactive drug metabolites (in particular acyl glucuronides) in relation to their impact on drug allergy and other toxicological consequences and of ii) plasma lipoproteins in order to develop better instrumental techniques for use as diagnostic tools in relation to cardiovascular diseases and cancer. An important aim is also to establish a network for the training of researchers in the analytical chemical and adjacent techniques developed in this RTD project. The proposal gives the background for the two research areas in which we think our research will provide new knowledge. The new knowledge on hyphenation will be exploited by Bruker Analytische Messtechnik and will ultimately be published in international journals. The proposal describes how the objectives will be fulfilled by completing a number of task :
1. Development of methods in HPLC-NMR (including chiral separations), micropore HPLC-NMR and CE-NMR
2. Development of HPLC-NMR and CE-NMR methods for lipoprotein analysis.
3. Analysis of lipoprotein and oxidised lipoprotein composition in normal and abnormal plasma by NMR.
4. Synthesis of model and drug glucuronides.
5. Use of 1H and l9F NMR and HPLC-NMR to derive transacylation kinetics.
6. Quantitative structure-activity studies on transacylation using computional chemistry properties.
7. Characterisation of drug glucuronide/protein condensation products.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine allergology drug allergy
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- natural sciences chemical sciences electrochemistry electrophoresis
- natural sciences chemical sciences analytical chemistry mass spectrometry
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2100 COPENHAGEN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.