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Content archived on 2024-05-14

Automatic System for Peptide Synthesis

Objective



The main aim of this project programme is represented by the design, the assembly and the test phases of an original system for the automated solid-phase synthesis of biopolymers, eg. petides and proteins. In line with market demands, the synthesise will be designed in order to carry out optimised chain assembly utilising the most widely used chemical strategies, i.e. both t-Boc and Fmoc chemistry. The synthesiser will be operated under computer control through dedicated software that will permit the operator not only to select a specific procedure from a range of different pre-programmed synthetic routes, but also to assemble personalised new ones: thus, the distinctive feature of the apparatus will be its extreme flexibility that will allow an easy up scaling of the process. A further original feature of the apparatus will be its plumbing scheme, which will be designed to facilitate optimization of the process from an engineering point of view: the presence of two reaction vessels (reactor and activator) set in separate hydraulic loops and served by two different pumps with independent delivery lines, will enable different chemical operations to be carried out at the sale time, thus, the total time required for each synthetic cycle will be dramatically reduced. The final goal of this project will be represented by the assembly of suitable devices to monitor the extent of the key reactions of solid phase synthesis process and the formulation of appropriate algorithms to control the entire synthetic process automatically.

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Funding Scheme

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EAW - Exploratory awards

Coordinator

Talent Srl
EU contribution
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Address
Via Follatoio 12
34148 Trieste
Italy

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Total cost

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Participants (1)

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