Objective
This proposal aims to develop and test a user friendly kit for the diagnosis and identification of opportunistic fungal pathogens. These are a frequent, and often life-threatening complication in immunocompromised patients e.g. AIDS. Studies show that at least 58-81% of all AIDS patients contract a fungal infection at some stage during their illness, with a mortality rate of 10-20%, and similar incidences and indeed consequences in Transplant patients. Two of the most common opportunistic fungal pathogens prevalent in immunocompromised patients are Aspergillus spp. and Candida spp. Resulting systemic infections incur an extremely high mortality rate and require aggressive therapy. The importance of early diagnosis for effectove therapy, connot be overemphasised. DNA probe technology offers significant advantages over current testing methods in terms of both speed and accuracy. The proposed research will involve the identification and design of specific probes fpr Aspergillus spp. and Candida spp., and the incorporation of the probes into assay formats which will allow the clinician to distinguish between different fungal pathogens. Preparation methods for the extraction of DNA clinical samples will also be examined. After the development of a Kit, it will be necessary to perform extensive clinical trials before its sensitivity and specificity can be guaranteed. Clinical partners will be sought during the exploratory phase to advise on the appropriate formats on the panel of fungal pathogens and to perform phase 1 clinical trials. The partners will include experts in AIDS.HIV and Transplantation fields.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences microbiology mycology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
90 GALWAY
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.