Objective
Objectives:
The present project is a shared cost action to develop a coordinated set of actions between a number of research and clinical centra aimed at identifying the genes involved in the susceptibility to SLE and SS, to determine the function of such genes and their interaction with environmental factors, as well as exploit the possibility of using this information in diagnostic and therapeutic strategies.
THE GENETICS OF SYSTEMIC LUPUS ERYTHEMATOSUS AND SJOGREN'S SYNDROME:A STRATEGY FOR IDENTIFICATION OF SUSCEPTIBILITY GENES IN TWO RELATEDDISORDERS.SHORT TITLE: The genetics of systemic autoimmune diseases. Systemic, chronic autoimmune diseases affect 2% of the general population. Among such disorders are included rheumatoid arthritis (RA), systemic lupuserythematosus (SLE), Sjgren's syndrome (SS) and overlapping disorders. These diseases affect mainly females above 30 years of age and often require an aggressive treatment with serious side effects Invalidation, renal transplantation and lymphoma development are common and serious features of RA, SLE and SS, respectively. Furthermore, there is evidence for common genetic mechanisms between these diseases and with other autoimmune disorders. The present project is proposed as a shared cost action (SCA) to develop a coordinated set of actions between a number of research and clinical centra aimed at identifying the genes involved in the susceptibility to SLE and SS, to determine the function of such genes and their interaction with environmental factors, as well as exploit the possibility of using this information in diagnostic and therapeutic strategies. The present SCA includes the participation of an industrial partner which may prove to be an interesting collaborative alternative for the whole partnership.
The following specific objectives will be pursued by this SCA:- Implementation of a common and well structured clinical method for the database on the patients and their relatives including serology;- Formation of a European DNA and RNA repository for SLE and SS;- Identification of the chromosomal regions and the genetic variants involved in the susceptibility to SLE and SS;- Use of animal models for SLE and SS in comparative genetic studies;- Development of diagnostic and risk assessment markers for clinical use.
The proposed action will yield important information concerning disease pathogenesis in a group of chronic autoimmune diseases. An important European information base for such disorders will be implemented and will be open to interested researchers through computerized information systems (World Wide Web).
Keywords: systemic lupus erythematosus, Sjgren's syndrome, autoimmune disease, animal models, immunogenetics, lupus nephritis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences basic medicine immunology autoimmune diseases
- natural sciences biological sciences genetics RNA
- medical and health sciences clinical medicine transplantation
- natural sciences computer and information sciences internet world wide web
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
751 23 Uppsala
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.