* To assess the impact of exposure to sunbeds on melanoma risk.
* To study risk determinants of melanoma arising in body areas normally not exposed to sunlight (MUS) and of non-lentigo melanoma of the head and neck (HNM).
BACKGROUND: An increased risk of melanoma seems associated with sunbed use, but we are still unable to quantify the amount of risk associated with that fashion. Surveys indicate that in 1995, between 15 and 50% of Northern European subjects were using sunbeds. Defining norms for sunbed commercialisation and use remains a difficult exercise due to the absence of sufficient data on actual impact of sunbed exposure in humans. Risk determinants of melanoma arising in body areas normally not exposed to sunlight (MUS) and of non-lentigo melanoma of the head and neck (HNM) are not well understood.
1) To assess the impact of exposure to sunbeds on melanomarisk;
2)To study risk determinants of MUS and HNM.
METHODS: multicenter case-control study including at least 600 melanoma cases aged 15 to 39 years old and 600 controls chosen at random in the same municipality. Young subjects are best suited for exploring the sunbed issue: rising melanoma incidence is more marked among them, they display the highest exposure rate to sunbeds, they are less prone to recall bias, and have the most hazardous behaviours towards the sunlight. 360 Subjects of all age presenting with MUS or HNM with 360 controls will also be included. MUS and HNM being partof the young melanoma sample will indeed be part of the later sample.
SIDE STUDIES: In order to increase our understanding of biological mechanisms active in melanoma, two side studies are planned. Side Study I: production of pheomelanin could be a strong genetically determined risk factor for melanoma. Pheo- to eumelanins ratio will be compared in subsamples of cases and controls.
Side Study II: Presence of p53 VUB signature mutations will be assessed in adjacent normal skin on selected young male cases of MUS and of trunk melanoma. Comparison of overall functional capacity of p53 will be compared between 20 selected young melanoma patients and 20 healthy controls. To maximize our comprehension of gene-environment interactions, Side Studies I and II will examine the same sample of melanoma cases.
PUBLIC HEALTH RELEVANCE: This research represents an opportunity for producing high quality data upon which to devise public health and economic policies about sunbed use. Side studies will enable to better define high risk subjects, and thus target prevention efforts intended to stop the rising melanoma incidence in our countries, mainly among young adults.
Keywords: Melanoma, Sunbed, Epidemiology, Molecular epidemiology, Genetic marker, prevention, public heath policy. 02 02
Funding SchemeCSC - Cost-sharing contracts
3008 AE Rotterdam
E1 2AT London
171 76 Stockholm