Objective
Considerable advances have made recently in understanding the molecular biology of prion propagation, although many issues remain unresolved. New variant CJD appears to represent transmission of BSE to humans, and it remains to be seen if many more cases will arise. Because of the long incubation period of these diseases the peak of any such epidemic may be as long as 10-15 years ahead. Therapeutic targets are becoming apparent and the development of rational therapeutics appears increasingly realistic. This proposal aims to bring together a number of groups with different but complementary expertise in this area to explore a number of key areas which will underpin the development and assessment of therapeutics. We will attempt to modify PrPC expression and availability, study the effects of PrP polymorphism on PrPSc formation and develop peptides which bind avidly to PrPC and PrPSc, and which may affect PrPSc formation. Cell culture and transgenic models have already been developed and will be further characterised and the range of strain diversity in human prion diseases will be fully determined. As any useful therapy will act at or before onset of the earliest neuropathological changes, these early events in the brain will be characterised and cell populations at particular risk identified. It is anticipated that such studies, in addition to advancing our understanding of prion biology and assessing therapeutic strategies, will help understand fundamental mechanisms of neurodegeneration that may be relevant to other, commoner neurodegenerative diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W2 1PG LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.