Objective
Near patient testing has brought with it major benefits, particularly with regard to the reliability and efficiency with which the management of the critically ill patient is now achieved. The continuous feedback possible with some recent systems, Furthermore, allows ongoing titration of therapies with undoubted added benefits for final outcome, particularly in clinical states where aggressive treatment is required and where even marginal changes in therapeutic manoeuvres have a major impact on outcome. The core parameters that are the most import ant to monitor on a continuous basis are pH, PO2, pCO2, glucose and K+ (conclusion of EU Concerted Action ERB BMHI CT92 0015). However, to date, no viable, lo w cost or operationally simple monitor is available and widespread benefit for the EU healthcare system unlikely from existing cumbersome commercial samples.
The basic analytical chemistry of the proposed parameters is well established, and it is the intention of the proposers to now integrate this into robust clinically feasible prototype monitoring equipment suitable for cardiopulmonary by pass, dialysis and general intensive care. Most importantly, it is intended to achieve a versatile calibration free monitor that for the first time removes the need for complicated drift/accuracy checks on the part of the clinical operator, and which can ultimately serve as a platform for further products in different (non health care) sectors. The technical objective will be a monitor with single sensors and sensor arrays that slot (in series) into existing extra corporeal blood sampling lines (venous and arterial). The sensors would exploit full optical spectral data emanating from analyse sensitive fluorescent/reflective membranes structured to give high blood compatibility. Unique to the system will be high level data processing able to
(i) deal with whole spectra
(ii) m ake sense of systematic spectral variants. The required subcomponents are individually robust, but work is required to fully optimise, evaluate and integrate these.
The programme will result in architecture design of a prototype monitor based uniquely on the following:
optoelectronic arrays;
packaging sensor membranes; selective chemical indicators (fluorescent lifetime intensity; reflectance);
knowledge based signal processing. From the user's perspective, the monitor would simply require to be linked to flow line sensors without further set-up. Evaluation in blood flow lines will be undertaken as a preliminary to establishing standard operating procedures and system design for manufacture.
Product aim is cost/size comparability with discrete laboratory bench top analysers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences analytical chemistry
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering signal processing
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences computer and information sciences data science data processing
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
M15 6SZ Manchester
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.