Objective
The present multi-disciplinary research prograrnme aims at the development of novel molecular and nanoscale drug delivery systems. The r esearch will be directed to the production of liposomes, molecular delivery systems based on dendrimers, lipid/ polymer aggregates, microgels and microspheres. The new microparticulated systems will be extensively characterized regarding their physical, chemical and clinical properties and interaction with biological material. Kinetic studies of the release behaviour of the active ingredients from the new drug delivery systems will be carried out and mathematical models will be developed to describe the release kinetics. Specifically, the research efforts will be focused on the following scientific and industrial objectives:
1. Preparation of functional and stabilized liposomes in which biologically active compounds will be incorporated. Active ingredients in liposomes will be protected by the incorporation of appropriate photostabilizers and antioxidant additives.
2. Preparation of aggregates from liposomes and polymeric surfactants and incorporation of active compounds The new delivery systems will be suitable candidates as synthetic vectors for the transfection of cells with biologically active compounds (e.g. nucleic acids in gene therapy).
3. Preparation of dendrimers based nanoparticles and the incorporation of active compounds within the molecular cavities of dendrimers. 4. Preparation of novel carriers in the form of nano and microspheres in which biologically active compounds will be incorporated
5. In vitro and in-vivo drug delivery studies of the new formulations. 6. Kinetics of drug release from the various systems prepared
Potential applications (e.g. new transdermal and oral drug delivery devices) will be based on advances in our understanding of the mechanism and kinetics of drug release from molecular and nano scale drug delivery systems, and the processes by which the systems are manufactured. Equally important will be the investigation and the quantifications of the relationships between process parameters and the release performance of the new delivery systems. It is envisaged that the new delivery systems will:
Prolong the action of the drug in the body through slow release of the active ingredient
Provide control over the site of release, the onset, and the intensity of action of the active ingredient
Increase the protection of the active molecules from light and oxygen
Improve the effectiveness of administration
Increase the solubilization of lipophilic or hydrophilic moleculesImprove the tissue and organ specificity (targeting properties)
All of the results of this study will have direct implications in the development of a new generation of molecular / nano scale controlled drug delivery systems. The results of this work is expected to find application in the biochemical, pharmaceutical, cosmetics, food, and agrochemical industries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences biochemistry biomolecules lipids
- engineering and technology nanotechnology nano-materials
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
54006 Thessaloniki
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.