Objective
Medical Devices represent half of the nosocomial complications in the hospital (25 40 % of intravenous catheters are infected after 5 7 days). They are related to a relative affinity of bacteria to adhere on an artificial surface, and to develop a biofilm structure which isolate microorganisms from conventional therapies.
End users and Industrials are highly concerned by morbidity and health care costs of infection. Although antibiotic bounding and silver treatment of the materials have already been proposed, their efficacy, safety and long term performances have not been established. This fundamental research program is dealing with the screening of more than 10 different surface treatment for polymers in order to design an "anti bacterial" interface.
These techniques of potential interest in developping antibacterial surfaces will include: Design of specific antibacterial activity (silver, quaternary ammonium, carbon like coating + Ag, silver iodide, antiseptics).
Grafting of biological molecules within the bulk or on the surface (heparin is of high potential interest).
Development of non fouling surfaces concept (PEO like, PEO
repelling, teflon like, suprahydrophilic, microstructurated)
The activity of these materials will be screened on bacterial strains and in conditions representative of the clinical use. A fundamental approach of biofilm expression and regulation according to the different polymeric surfaces and treatments is included as an important step for the understanding of the effects.
The project will be in a second time (after month 20) restricted to efficient surface treatments and to those for which the risk benefit ratio is acceptable.Polymeric changes induced by the treatment, optimization of sterilization conditions will be investigated.
5 academic partners who developped and fully control these
technologies and 5 industrial partners, including 2 CRO's, will participate to this extensive project. Due to its important impact, the project is exceeding 30 % of the total cost allowed for basic research projects. However, this size expresses also the need for an EU level programme since no single partner would be able to develop it individualy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences biological sciences biochemistry biomolecules
- engineering and technology materials engineering coating and films
- engineering and technology industrial biotechnology biomaterials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
38670 CHASSE SUR RHONE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.