Objective
Over the last two decades the development of biomaterials for orthopedic application has been directed towards achieving complete integration of the prosthetic material with bone tissue. While advances have been made, osteogenesis is still limited and ultrastructural studies indicate incomplete integration for most implant systems. This proposal presents novel surface bioactivation procedures to improve the osteointegrative properties of mechanically suited biomaterials. It specifically directs towards porous biomaterials formulated to create phospholipid-rich microenvironments, which will induce calcium phosphate deposition and encourage collagen mineralisation.
Candidate systems will be developed from titanium/hydroxyapatite-coated alloys and novel acrylate co-polymers. Material surfaces will be modified to offer controlled surface porosity; phospholipid- coating approaches will draw upon formulation methodologies already successfully applied in pharmaceutical development. Deposition of calcium-binding phospholipids or entrapment of calcium-permeable liposomes in biomaterial pores will achieve surface bioactivation. Localisation of calcium within, or influx into, a phosphate-rich interior will result in calcium phosphate deposition in the pores with consequent matrix mineralisation; a process reflective of the physiological role played by membrane vesicles during bone regeneration. In a second approach, porous polymer surfaces will be functionalised by copolymerisation with phosphate-ester based methacrylate monomers. Each pore will represent a microenvironment capable of creating a calcium-rich layer favouring osteoblast integration and mineralisation. Biomimetic bioactive phospholipid-based porous matrices will provide options for coating and monolith technologies offering improved osteointegration properties BE97-4384.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences chemical sciences polymer sciences
- engineering and technology materials engineering coating and films
- engineering and technology industrial biotechnology biomaterials
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BN2 4GJ Brighton
United Kingdom
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