Objective
Objectives and content
Zwitterionic molecules have an amphoteric ion structure,
bearing permanent cationic and anionic groups. Because
of their permanent zwitterionic group these molecules
offer a number of advantages: special adhesion behaviour,
excellent electrolyte stability and biocompatibility, and
have potential application in biology or medicine. In
this context, sulfobetaines are particularly useful as
they are completely stable and resist hydrolysis.
Elastomeric materials, especially based upon siloxanes
are intensively used in medical devices for their high
flexibility, tear resistance and hydrophobicity. Despite
an other important property, their high oxygen
permeability, the only medical field where these silicone
rubbers are not used is the contact lens industry. For
many years contact lenses manufacturers have attempted to
develop new materials for safe extended wear (SEW)
contact lenses, but without success. These elastomeres
were found to be good materials as contact lenses, except
for lacking adequate surface properties: hydrophilicity
and, protein and lipids deposit resistance.
Now a better understanding of the key factors affecting
ocular compatibility and in general biocompatibility
would enable the development of a new elastomeric contact
lens material suitable for SEW and a new class of
molecules with potential application in the improvement
of other medical device materials.
The following points will be addressed:
Development of a Model Elastomeric Material by chemical
grafting of silicone elastomeres. The chemical grafting
will modify dynamic and tribological surface properties
of the elastomeric material. The study and
quantification of the surface property will allow a
better understanding of the factors affecting ocular
compatibility
Preparation of modified monomer and oligomere
intermediates: surfactants, monomers and macromonomeres,
usable for surface properties modification and
optimisation of elastomeric materials
Manufacturing of prototype elastomeric contact lenses
and full characterisation: oxygen transmissibility,
optical and mechanical properties, cytotoxicological
properties, in-vitro surface and interfacial behaviour
Development and validation of in-vitro methods for the
assessment of ocular compatibility of elastomeric
materials.
This research will be conducted thanks to an interactive
collaboration between leading European Industries and
Universities which have expertise in optics, polymer
synthesis, surface analysis and biological
characterisation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences physical sciences optics
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
94000 Créteil
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.