Objective Objectives and content Bioresorbable implants for bone stabilisation after fracture offer substantial advantages. The social and economic costs of secondary procedures to remove metal implants are immense. It has been estimated that half of the world population will suffer a fracture at some time in their lives and although many are managed conservatively, up to 75% require reduction and internal fixation with pins, screws and plates. At the same time there are major practical problems with current resorbable implants, which may be structurally inadequate for the biomechanical demands, are resorbed at unpredictable speeds and may become infected prior to resorption. This project is designed to take novel improved biomaterials and, with the help of injection moulding techniques, to produce composite implants of complex design for more effective bones stabilisation. Research tasks include: selection and characterisation of materials. improving the interfacial properties of selected bioceramic/bioresorbable polymer. adaptation of injection moulding techniques for new composite implants. specifying product design. biomechanical assessment of implant strength. experimental testing of implants in vitro and in appropriate animal models. investigation of antibiotic incorporation for prophylaxis against infection. The consortium comprises orthopedic surgeons for design and evaluation (ICSTM), a research and development institute to assist with compounding and processing (DTI), an industrial laboratory for testing biomaterials (LEMI), major manufacturers of resorbable polymers (PURAC) and pharmaceutical products including antibiotics (LEO), an interdisciplinary research centre which has produced a bioactive composite which is in clinical use (QMW), a producer of bioresorbable and bioactive ceramics (FIN-CERAMICA) and an SME with a proven track record in the marketing of first and second generation bioresorbable implants (PHUSIS). Fields of science engineering and technologymaterials engineeringcompositesnatural scienceschemical sciencespolymer sciencesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesmedical biotechnologyimplants Programme(s) FP4-BRITE/EURAM 3 - Specific research and technological development programme in the field of industrial and materials technologies, 1994-1998 Topic(s) 0201 - Materials engineering Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Dansk Teknologisk Institut Address Gregersensvej 2630 Taastrup Denmark See on map EU contribution € 0,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all FIN- CERAMICA FAENZA SRL Italy EU contribution € 0,00 Address Via granarolo 102 48018 Faenza See on map Imperial College of Science Technology and Medicine United Kingdom EU contribution € 0,00 Address Fulham palace road W6 8RF London See on map LABORATOIRE D'EVALUATION DES MATÉRIELS IMPLANTABLES France EU contribution € 0,00 Address Technopole montesquieu 33650 Martillac See on map Leo Pharmaceutical Products Denmark EU contribution € 0,00 Address 55,industriparken 2750 Ballerup See on map Phusis Matériaux Biorésorbables S.A. France EU contribution € 0,00 Address 58,route du rivet 38330 St. imier See on map Purac Biochem BV Netherlands EU contribution € 0,00 Address 46,arkelsedijk 4200 AA Gorinchem See on map QUEEN MARY AND WESTFIELD COLLEGE - UNIVERSITY OF LONDON United Kingdom EU contribution € 0,00 Address Mile end road E1 4NS London See on map
