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Bio-resorbable implants for minimal access surgery

Objective



Objectives and content
Bioresorbable implants for bone stabilisation after
fracture offer substantial advantages. The social and
economic costs of secondary procedures to remove metal
implants are immense. It has been estimated that half of
the world population will suffer a fracture at some time
in their lives and although many are managed
conservatively, up to 75% require reduction and internal
fixation with pins, screws and plates.
At the same time there are major practical problems with
current resorbable implants, which may be structurally
inadequate for the biomechanical demands, are resorbed at
unpredictable speeds and may become infected prior to
resorption.
This project is designed to take novel improved
biomaterials and, with the help of injection moulding
techniques, to produce composite implants of complex
design for more effective bones stabilisation.
Research tasks include:
selection and characterisation of materials.
improving the interfacial properties of selected
bioceramic/bioresorbable polymer.
adaptation of injection moulding techniques for new
composite implants.
specifying product design.
biomechanical assessment of implant strength.
experimental testing of implants in vitro and in
appropriate animal models.
investigation of antibiotic incorporation for
prophylaxis against infection.
The consortium comprises orthopedic surgeons for design
and evaluation (ICSTM), a research and development
institute to assist with compounding and processing
(DTI), an industrial laboratory for testing biomaterials
(LEMI), major manufacturers of resorbable polymers
(PURAC) and pharmaceutical products including antibiotics
(LEO), an interdisciplinary research centre which has
produced a bioactive composite which is in clinical use
(QMW), a producer of bioresorbable and bioactive ceramics
(FIN-CERAMICA) and an SME with a proven track record in
the marketing of first and second generation
bioresorbable implants (PHUSIS).

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Dansk Teknologisk Institut
Address
Gregersensvej
2630 Taastrup
Denmark

Participants (7)

FIN- CERAMICA FAENZA SRL
Italy
Address
Via Granarolo 102
48018 Faenza
Imperial College of Science Technology and Medicine
United Kingdom
Address
Fulham Palace Road
W6 8RF London
LABORATOIRE D'EVALUATION DES MATÉRIELS IMPLANTABLES
France
Address
Technopole Montesquieu
33650 Martillac
Leo Pharmaceutical Products
Denmark
Address
55,Industriparken
2750 Ballerup
Phusis Matériaux Biorésorbables S.A.
France
Address
58,Route Du Rivet
38330 St. Imier
Purac Biochem BV
Netherlands
Address
46,Arkelsedijk
4200 AA Gorinchem
QUEEN MARY AND WESTFIELD COLLEGE - UNIVERSITY OF LONDON
United Kingdom
Address
Mile End Road
E1 4NS London