Objective
Objectives and content
Bioresorbable implants for bone stabilisation after
fracture offer substantial advantages. The social and
economic costs of secondary procedures to remove metal
implants are immense. It has been estimated that half of
the world population will suffer a fracture at some time
in their lives and although many are managed
conservatively, up to 75% require reduction and internal
fixation with pins, screws and plates.
At the same time there are major practical problems with
current resorbable implants, which may be structurally
inadequate for the biomechanical demands, are resorbed at
unpredictable speeds and may become infected prior to
resorption.
This project is designed to take novel improved
biomaterials and, with the help of injection moulding
techniques, to produce composite implants of complex
design for more effective bones stabilisation.
Research tasks include:
selection and characterisation of materials.
improving the interfacial properties of selected
bioceramic/bioresorbable polymer.
adaptation of injection moulding techniques for new
composite implants.
specifying product design.
biomechanical assessment of implant strength.
experimental testing of implants in vitro and in
appropriate animal models.
investigation of antibiotic incorporation for
prophylaxis against infection.
The consortium comprises orthopedic surgeons for design
and evaluation (ICSTM), a research and development
institute to assist with compounding and processing
(DTI), an industrial laboratory for testing biomaterials
(LEMI), major manufacturers of resorbable polymers
(PURAC) and pharmaceutical products including antibiotics
(LEO), an interdisciplinary research centre which has
produced a bioactive composite which is in clinical use
(QMW), a producer of bioresorbable and bioactive ceramics
(FIN-CERAMICA) and an SME with a proven track record in
the marketing of first and second generation
bioresorbable implants (PHUSIS).
Fields of science
- engineering and technologymaterials engineeringcomposites
- natural scienceschemical sciencespolymer sciences
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- engineering and technologyindustrial biotechnologybiomaterials
- medical and health sciencesmedical biotechnologyimplants
Topic(s)
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
2630 Taastrup
Denmark
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Participants (7)
48018 Faenza
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W6 8RF London
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33650 Martillac
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2750 Ballerup
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38330 St. Imier
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4200 AA Gorinchem
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E1 4NS London
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