Currently crystal glass contains either 24% or 32% lead. In use, lead may leach from crystal into liquids which may be subsequently drunk, resulting in lead intake by the general public. This intake is regarded as unacceptable by groups in some countries (e.g. USA) and therefore there is pressure to remove lead from crystal and replace it with G safer substitute. Whilst a lot is known about lead toxicity, relatively little is known the bioavailability, toxicity and behaviour of substitutes in the body The aim of the project is to provide the European Crystal Industry with the biological information for the production of a safety case for genetic unleaded crystal compositions.