Objective
Medical and veterinary science is increasingly using antibodies and other large protein-based biomolecules as vaccines and as therapy for a wide range of diseases. The production of these agents has been one of the driving forces behind the development of biotechnology. Indeed, the volume production of many proteins (e.g. interferon) is now possible. However, the subsequent processing of the protein substance for consumption presents a number of problems. Firstly, their is the need for very specific extraction and purification of the protein from the source, whether itt be natural or as a result of a biotechnological process. Most current extraction/purification processes do not offer an economically viable balance between purity and yield. Secondly, these substances are susceptible both to atmospheric oxidation and temperature/pH changes, and this can result in the denaturing of large proportions of the desired product, reducing its effectiveness. These problems are the major limiting factor in the exploitation of protein-based pharmaceutical products. The development of a continuous flow, in line extraction/encapsulation process, with a high level of environmental control, would allow the efficient production of these fragile substances at relatively low-cost, in an encapstulated form resistant to deterioration. Supercritical fluid extraction (SFE) has now progressed (with the demonstration of supercritical fluid microemulsions) to become a viable method of extracting proteins with high purity and yield. In addition, there are a number of approaches to encapsulation of proteins which can be incorporated with the extraction as a continuous, in-line process. This project will focus on the fundamental development of a continuous, in-line extraction and encapsulation process for protein bioimolecules. A number of issues will be addressed; - The development of a demonstrated SFE concept for the volume extraction of a number of test pharmaceutical proteins. - The development of suitable in-line encapsulation techniques, to protect the proteins from deterioration once extracted. - The incorporation of both extraction and encapsulation into a controlled, continuous, in-line process.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences veterinary sciences
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- social sciences sociology governance environmental governance
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
13705 MARIGNANE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.