Objective
The major scientific goal of this project concerns the induction, maintenance and breakdown of immune tolerance which will be approached using transgenic technology and gene targeting. Understanding the cellular and molecular mechanism which are involved in self tolerance may allow one to influence the process of auto immunity in human disease. Moreover, this knowledge will be invaluable in transplantation rejection, viral diseases and tumor immunology where it is suspected that tumors may induce tolerance in the periphery. All the laboratories involved in this network are already using transgenic technology. A more recently develop technique in this field is the introduction of specific mutations into the mouse germ line by homologous recombination in embryonic stem cells (gene targeting). This approach will rely on the exchange and the interbreeding of the mouse mutants generated by gene targeting and the conventional transgenic technique.
Transgenic and knock out mice for the study of induction, maintenance and breakdown of immune tolerance have been generated. In the first year the various mouse models have been produced and in the second year the mice will be analysed and used as models for human disease. Interdependence between tasks consists in making available to all the network's participants the homologous recombination technology through education and mobility and in sharing transgenic and knock out animals for further development of mouse models for autoimmune diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine immunology autoimmune diseases
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20129 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.