Objective The major scientific goal of this project concerns the induction, maintenance and breakdown of immune tolerance which will be approached using transgenic technology and gene targeting. Understanding the cellular and molecular mechanism which are involved in self tolerance may allow one to influence the process of auto immunity in human disease. Moreover, this knowledge will be invaluable in transplantation rejection, viral diseases and tumor immunology where it is suspected that tumors may induce tolerance in the periphery. All the laboratories involved in this network are already using transgenic technology. A more recently develop technique in this field is the introduction of specific mutations into the mouse germ line by homologous recombination in embryonic stem cells (gene targeting). This approach will rely on the exchange and the interbreeding of the mouse mutants generated by gene targeting and the conventional transgenic technique.Transgenic and knock out mice for the study of induction, maintenance and breakdown of immune tolerance have been generated. In the first year the various mouse models have been produced and in the second year the mice will be analysed and used as models for human disease. Interdependence between tasks consists in making available to all the network's participants the homologous recombination technology through education and mobility and in sharing transgenic and knock out animals for further development of mouse models for autoimmune diseases. Fields of science medical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesnatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicinetransplantation Programme(s) FP3-HCM - Specific research and technological development programme (EEC) in the field of human capital and mobility, 1990-1994 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Università degli Studi di Milano Address Via vanvitelli 32 20129 Milano Italy See on map EU contribution € 0,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all Institut National de la Santé et de la Recherche Médicale (INSERM) France EU contribution € 0,00 Address Parc scientifique de luminy 13288 Marseille See on map Institut Pasteur France EU contribution € 0,00 Address Rue du docteur roux 25 75724 Paris See on map Roche SpA Italy EU contribution € 0,00 Address Piazza durante 11 20131 Milano See on map Stiftung Deutsches Krebsforschungszentrum Germany EU contribution € 0,00 Address Im neuenheimer feld 280 69120 Heidelberg See on map UNIVERSITAET KOELN Germany EU contribution € 0,00 Address Carl-von-linné-weg 101 50829 Köln See on map
