Objective
The research groups of the network will collaborate by approaching the complex theme of the study of the interactions between inorganic systems and nucleic acids and their related pharmacological effects, especially their antitumour activity, by different complementary methods. The different themes that will be developed are platinum-based, ruthenium-based, other transition metal-based and tin-based antitumour drugs.The results one can expect from this type of investigation are: finding of new inorganic drugs and new insights in the structure-activity relationship; a better understanding of metal nucleic acid functionality and their role within the living systems; and a better knowledge of the relevance on metals in the living matter, together with their physiological and toxicological effects.
Research groups have collaborated in the study of the interactions between inorganic systems and nucleic acids and their related pharmacological effects, especially their antitumour activity, by different complementary methods. Results are as follows:
the interaction between platinum and palladium based antitumour drugs and nucleic acids has been studied, and structural investigations of binary peptide and ternary peptide nucleobase complexes of palladium(II) as well as of mixed platinum(II)-palladium(II) and platinum(II)-mercury(II) cytosine nucleobase compounds has been carried out;
the distortions induced in deoxyribonucleic acid (DNA) by cis or trans diamminedichloroplatinum (DDP) interstrand cross links have been characterized by deoxyribonuclease (DNase) I footprinting experiments;
the structures of the photoadducts formed between the guanosine-5'-monophosphate (GMP) and several ruthenium(II) complexes of polyazaaromatic ligands like Ru(TAP)32+ have been determined; it has been shown that the adduct is formed via covalent binding of a TAP ligand to the nitrogen 2 of guanine;
a series of diethylenetriamine pentaacetic acid (DTPA) bis amides and their lanthanum(III) complexes were prepared and characterized, as potential contrast agents for magnetic resonance imaging (MRI);
the substitution of hydrogen of fluorine, increasing the solubility of organotin compounds, has been shown to increase also their in vitro antitumour properties against human tumour cell lines.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- natural sciencesbiological sciencesgeneticsDNA
- natural scienceschemical sciencesinorganic chemistrytransition metals
- natural scienceschemical sciencesinorganic chemistryhalogens
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
1050 Bruxelles
Belgium
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Participants (22)
WC1H 0PP London
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31077 TOULOUSE
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45071 ORLEANS
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75270 PARIS
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2300 RA Leiden
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15780 Athens
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2 Dublin
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69120 Heidelberg
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4 Dublin
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41012 SEVILLA
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BARCELONA
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46100 BURJASOT
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5007 BERGEN
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34127 Trieste
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6177 Santiago
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3000 Coimbra
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45110 Ioannina
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70125 Bari
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33100 Udine
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4056 Basel
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44201 Dortmund
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1050 Bruxelles
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