Objective
The objectives of this application are to incorporate two Hungarian laboratories into an existing Human Mobility Network to study genes that regulate progression through the cell cycle, utilising Drosophila and fission yeasts as model organisms. The existing West European Network will generate mutants defective in cell division, study their phenotypes, and devise means for the molecular cloning of selected genes. The Hungarian laboratories offer two exciting contributions to this Network in the form of collections of Drosophila mutants, a large number of which affect cell cycle progression. professor szabad's laboratory has established a collection of dominant female sterile mutants, from which only a few mutant loci have been characterised. These lead to abnormal embryonic development, in many cases because of the maternal contribution of an abnorml protein essential for either meiosis or mitosis. It is proposed to study the phenotype of double mutant combinations between these mutants and others known to affect this developmental stage in an attempt to establish regulatory hierarchies. Selected loci will be selected for cloning and further molecular studies. Dr Kiss' laboratory has established a collection of more than 2700 lethal and semi-lethal mutants resulting from the insertion of single p-transposons. Already some 20 mitotic mutants have been identified in this collection. It is proposed to carry out a detailed study of the mitotic defects in these mutants, and to undertake the molecular cloning and characterisation of several of these loci. The research groups in the Network will exchange reagents and mutants, and their combined activities will better our understanding of cell cycle regulation. Genes that regulate the progression through the cell cycle have been highly conserved through evolution. We therefore expect that in the long term our findings will be generally applicable to a wide variety of human diseases in which cell division occurs abnormally, including cancer.
Fields of science (EuroSciVoc)
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DD1 4HN Dundee
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.