The role of membranes in lens ageing and cataract

Project Information

Grant agreement ID: CIPD940237

Project closed

Start date 1 April 1995

End date 31 March 1997

Funded under

• Scientific and technological cooperation between the European Community and European non-member countries, 1992-

Total cost € 0,00

EU contribution No data

Coordinated by

The Netherlands Ophtalmic Research Institute
Netherlands

Objective

Non-enzymatic glycosylation of proteins (glycation) is considered a main cause of nuclear cataract i.e. discoloration and increased light scatter of the lens nucleus with age. It leads to accumulation of yellow/brown pigments, appearance of non-tryptophan
fluorescence and formation of cross-linked proteins. Much less attention has been given to the effects of the glycation products or derivatives on the lens membranes and their physiological properties.In addition the relation between glycation and "autooxidation" of glucose and consequently of free radicals is underscored up till now. The present proposal aims to investigate the precise chemical course of glycation and the effects on membrane intrinsic proteins and the phospholipids and cholesterol of the membranes. As such this proposal is a welcome extension of the themes studied within the Concerted action.

Programme(s)

• IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992-

Topic(s)

• 0201 - CEEC participation in BIOMEDICAL AND HEALTH RESEARCH programme

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

The Netherlands Ophtalmic Research Institute

• EU contribution: No data
• Address: 1100 AC Amsterdam ; Netherlands
• Total cost: No data

Participants (1)

University of Plovdiv

Bulgaria

• EU contribution: No data
• Address: 24,Tzar Assen ; 4000 Plovdiv
• Total cost: No data