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Toxic effects from accidental releases of hazardous substances

Objective



Industrial plants, transport systems, etc., are regularly assessed with respect to the risk posed to nearby inhabitants due to accidents which involve the release of toxic chemicals.

The objective of this proposal is to develop and assess methodologies to determine the acute toxicity through inhalation of a number of hazardous substances for fluctuating concentration exposure and lethal and non-lethal damage.

This is relevant because of the concentration fluctuations in any cloud in the atmosphere. This means that in real life during accidental releases exposure may occur during short to very short time periods, separated by periods of zero concentration.

With respect to the toxic impact there is little knowledge about effects of exposure during extreme short periods.
Toxicity data, e.g. as used in the Probit-functions, is generally based on exposure averaged over at least 10 minutes, whereas the relevant timescales of concentration fluctuations can be of the order of a minute or less.
This proposal wants to address this problem by analysing working mechanisms of very acute acting toxic substances, by analysis of some experimental data and by attempting to provide model descriptions of the physical and chemical processes involved in the toxic impact through inhalation. The result will be concentration-time-effect relationships for a number of toxic substances and guidelines on the relevant timescales to be considered in quantitative risk assessment

Coordinator

Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek
Address
501,Laan Van Westenenk
7300 AH Apeldoorn
Netherlands

Participants (3)

Danmarks Farmaceutiske Højskole
Denmark
Address
2,Universitetsparken
2100 København Ø
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek
Netherlands
Address
48,Utrechtseweg 48
3700 AJ Zeist
RISOE NATIONAL LABORATORY
Denmark
Address
Frederiksborgvej 399
4000 Roskilde