Objective DEVELOPMENT AND VALIDATION OF ASSAYS TO EVALUATE CHEMICALS CAPABLE OF INDUCING GENOMIC MUTATIONS. EMPHASIS IS GIVEN TO THE FUNGUS ASPERGILLUS NIDULANS, WHICH OFFERS CONSIDERABLE PROMISE AS A SYSTEM FOR DETECTING GENOMIC MUTATIONS AND FOR UNDERSTANDING THE MECHANISMS OF SUCH MUTATION. THE WORK INCLUDES : I) THE USE OF THE DIPLOID STRAIN OF A NIDULANS TO DETECT CHEMICALLY INDUCED EUPLOID MITOTIC SEGREGANTS AS PRODUCTS OF NON-DISJUNCTION OR MITOTIC CROSSING-OVER. II) THE SYNTHESIS OF MARKED DIPLOID STRAINS TO DISTINGUISH INDUCED ANEUPLOIDY FROM CHROMOSOME BREAKS. III) INVESTIGATING THE POSSIBILITY OF USING METABOLIC ACTIVATION IN THE SYSTEM. IV) ESTABLISHING THE EFFECTS OF ANEUGENIC CHEMICALS ON TUBULIN ASSEMBLY. Fields of science natural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencesgeneticsmutationnatural sciencesearth and related environmental sciencesenvironmental sciencespollutionnatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP1-ENVPROT 4C - Multiannual research and development programmes (EEC) in the field of the environment - Protection of the environment -, 1986-1990 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Greek Atomic Energy Commission EU contribution No data Address Attikis 15310 Athens Greece See on map Total cost No data