Objective
1) STUDY OF MOLECULAR INTERACTIONS OF ENVIRONMENTAL MUTAGENS AND CARCINOGENS AT DNA LEVEL. 2) TO RELATE BIOLOGICAL CONSEQUENCES OF CHEMICAL MUTAGENS TO THE EXTENT AND SITE OF REACTION BETWEEN THE MUTAGENS AND DNA. 3) DEVELOPMENT AND VALIDATION OF METHODS TO IDENTIFY NON-GENOTOXIC CARCINOGENS. 4) DEVELOPMENT AND VALIDATION OF ASSAYS TO EVALUATE CHEMICALS CAPABLE OF INDUCING GENOMIC MUTATIONS.
1) AND 2) RELATIONSHIP BETWEEN IN VITRO AND IN-VIVO MUTAGENESIS: THE INDUCTION OF CHROMOSOME ABERRATIONS IN LYMPHOCYTES, HEPATOCYTES AND BONE MARROW CELLS, AFTER IN-VITRO OR IN-VIVO EXPOSURE TO MUTAGENS WITH A KNOWN DOSIMETRY WILL BE STUDIED, IN ORDER TO CORRELATE THE SAME GENETIC ENDPOINTS ON THE SAME CELL TYPE EITHER IN-VITRO OR IN-VIVO.
3) COMPARATIVE CHANGES IN THE TISSUES OF MICE TREATED IN-VIVO AND STUDIED IN-VITRO: CYTOGENIC ANALYSES WILL BE CARRIED OUT IN EPITHELIAL MOUSE CELLS IN-VIVO AND IN CULTURES OF THE SAME CELLS, AFTER TREATMENT WITH VARIOUS MUTAGENS AND TUMOUR PROMOTERS.
4) MICRONUCLEI IN-VITRO AND SOMATIC TISSUE IN-VIVO - ANEUPLOIDY IN MALE GERM CELLS;
I) EVALUATION OF CHROMOSOME NUMBER IN METAPHASES, THE PRESENCE OF MICRONUCLEI INTERPHASE HUMAN LYMPHOCYTES; ALSO IN SOMATIC CELLS OF DIFFERENT TISSUES OF RODENTS AFTER IN-VIVO TREATMENTS.
II) INDUCTION OF NUMERICAL ANOMALIES IN MOUSE GERM CELLS CAUSED BY THE SAME COMPOUNDS.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics mutation
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
56126 PISA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.