Objective
Determination of ultraviolet radiation-induced oncogene and tumour suppressor gene expression in humans of various skin types and ages and determination of the action spectrum in vivo in humans. The effect of UV-B radiation on the release of inflammatory and immunologic mediators will be studied in vitro and in human subjects in vivo relating the effects to skin type. The relationship between DNA photolesions and cytokine production in human keratinocytes will also be determined in vivo in different skin types. Identification and risk assessment of groups at risk of skin cancer. Assessment of methods of determining UV-B radiation susceptibility in humans with a view to developing an objective methodology.
The incidence of skin cancer, the commonest malignancy affecting man in the western world, is steadily rising, and with continued depletion of stratospheric ozone this trend is likely to become worse. The major risk factors for the development of skin cancer relate to UV-B radiation exposure and skin type. This proposal will examine the inflammatory, immunologic and carcinogenic effects of UV-B radiation relating each to skin type to see whether it is possible to identify those in the population most at risk of skin cancer. The dose and action spectrum of UV-B radiation required for these effects will enable more accurate prediction of the consequences of ozone depletion in the long term. Population studies of the prevalence of skin types will be carried out together with assessment of personal exposure. Standardisation of methods of measuring minimal erythema doses together with objective measurement of skin type will enable extrapolation of our results to the general population. These studies will greatly expand present knowledge of the effects of excessive sun-exposure on the skin. The complexity of the molecular events in human skin caused by excessive UV-B is such that further progress is possible only with a concerted approach as in this project. These studies will also greatly benefit each participating centre by increasing the scope of the laboratory and by providing access to new technology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer
- natural sciences biological sciences genetics DNA
- natural sciences earth and related environmental sciences environmental sciences ozone depletion
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.