Multi-organic risk assessment of selected endocrine disrupters

Objective

ED's with steroidal or anti-steroidal effects may be of great importance during embryonic development and later for metabolic, brain, cardiovascular, reproductive, and bone function. The effects of UV-absorbing chemicals (4-MDC, homosalate), characterised recently as estrogenic, and of Benzophenone D, a chemical used in cosmetics, as well as the fungicide Procymidone and the pesticide Linuron will be studied in rats and gene-targeted mice. High throughput methods to identify ED's with (anti) estrogenic (anti) androgenic, (anti) progestational, (anti) glucocorticoid, and (anti) thyroid hormone activities will be employed. Gene-targeted cell lines and animals, including the EU-sponsored EUROSTERONE DNA chip, will seek to quantify both ED's and their effects on gene and protein expression in different organs. This will lead to clear concepts for clinical trials towards the end of the project.

Programme(s)

• FP5-EESD - Programme for research, technological development and demonstration on "Energy, environment and sustainable development, 1998-2002"

Topic(s)

• 1.1.4.-1. - Key action Sustainable Management and Quality of Water

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN

Address

Robert-koch-strasse 40
37075 Goettingen
Germany

Participants (11)

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

United Kingdom

Address

2Nd Floor, Irdb Building, Imperial College, Hammer
W12 ONN London

INSTITUTE OF ANIMAL REPRODUCTION AND FOOD RESEARCH - POLISH ACADEMY OF SCIENCES

Poland

Address

Prawochenskiego 5
10 718 Olstzyn

KAROLINSKA INSTITUTE

Sweden

Address

Novum Huddinge Sjukhus
141 86 Huddinge

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

Address

Ciudad Universitaria
28040 Madrid

UNIVERSIDAD DE BUENOS AIRES

Argentina

Address

Paraguay 2155, Piso 7
1121 Buenos Aires

UNIVERSITAETSKLINIKUM CHARITE - MEDIZINISCHE FAKULTAET DER HUMBOLDT-UNIVERSITAET ZU BERLIN

Germany

Address

Schumanstrasse 20-21
10117 Berlin

UNIVERSITY OF EDINBURGH

United Kingdom

Address

Chalmers Street 37
EH3 9ET Edinburgh

UNIVERSITY OF HELSINKI

Finland

Address

Haartmaninkatu 8, Biomedicum Helsinki
00014 Helsinki

UNIVERSITY OF MEDICAL SCIENCES K. MARCINKOWSKI

Poland

Address

6 Swiecicki Street
60 781 Poznan

UNIVERSITY OF TURKU

Finland

Address

Kiinamyllynkatu 13
20014 Turku

UNIVERSITY OF ZURICH

Switzerland

Address

Winterthurerstrasse 190
8057 Zurich