Objective
ED's with steroidal or anti-steroidal effects may be of great importance during embryonic development and later for metabolic, brain, cardiovascular, reproductive, and bone function. The effects of UV-absorbing chemicals (4-MDC, homosalate), characterised recently as estrogenic, and of Benzophenone D, a chemical used in cosmetics, as well as the fungicide Procymidone and the pesticide Linuron will be studied in rats and gene-targeted mice. High throughput methods to identify ED's with (anti) estrogenic (anti) androgenic, (anti) progestational, (anti) glucocorticoid, and (anti) thyroid hormone activities will be employed. Gene-targeted cell lines and animals, including the EU-sponsored EUROSTERONE DNA chip, will seek to quantify both ED's and their effects on gene and protein expression in different organs. This will lead to clear concepts for clinical trials towards the end of the project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
37075 GOETTINGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.