Objective The important role of volatile halocarbon compounds in ozone depletion has attracted public concern and stimulated research into their production and biochemistry. Volatile iodinated compounds are produced naturally by brown macroalgae and are involved in the process of ozone degradation.Although many reports have shown that brown algae accumulate and extrude:- upon stress stimulation, the cellular mechanism that controls the transport of;- to the surrounding medium is still unknown. The general aims of this work are, therefore, to investigate how;- is transported across the plasma membrane during stress in brown algae. We propose to find and characterise the;- transport system via electrophysiology techniques (single channel patch clamp on laser microsurgery-isolated brown algae protoplasts) and to investigate the physiology of iodine fluxes by pharmacological approaches and radioactive tracer. The biochemical and molecular characterization of this channel and further functional analysis will provide anew insight on the biological;- fluxes regulation. This research is an extension of the applicant's previous work on oxidative stress signalling in the brown algae Fucus embryos but taking the research into the biochemical and molecular levels. The applicant will be welcomed to a large, active and productive research group with expertise in these areas. This project will add, thus, new skills to her scientific experience. To the group of Dr. Bernard Kloareg she will bring her expertise in stress signalling at the cellular level and electrophysiology. Both the candidate and the host institution will benefit from this exchange, and this project will allow some exciting science to be done which both applicant and host will gain. Fields of science natural sciencesbiological sciencesmicrobiologyphycologynatural sciencesearth and related environmental sciencesenvironmental sciencesozone depletionnatural scienceschemical sciencesinorganic chemistryhalogensnatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysisnatural scienceschemical sciencesorganic chemistryorganohalogen compounds Programme(s) FP5-EESD - Programme for research, technological development and demonstration on "Energy, environment and sustainable development, 1998-2002" Topic(s) 1.1.4.-3. - Key action Sustainable Marine Ecosystems Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE EU contribution No data Address Place Georges Teissier 29682 ROSCOFF France See on map Total cost No data
