Objective
Background :
Bovine brucellosis (BB) has been eradicated in most parts of Northern EU countries but herds must be monitored continously for the potential presence of the disease. An unacceptable prevalence of the infection persists in certain areas of EU member states. A high level of non-specific reactions to serological tests has recently emerged in several countries. Another bacteria, Yersinia enterocolitica O:9 (YO9), seems to be responsible for these cross-reactions. Unnecessary restrictions, waste of resources, genetic losses, failure to control the disease, as well as trade restrictions are some of the consequences of this situation.
The objective is :
This proposal aims at developing diagnostic tests able to differentiate infection by
Brucella abortus (BA) from infection by YO9. Blood tests based either on cellular or
humoral immunity detecting only the anti-BA response as well as tests to detect
specifically infections due to YO9 will be developed.
Short description of the project :
The project will consist of 7 main tasks:
- Development of a bovine gamma-interferon enzyme immunoassay for Brucella;
- Development of ELISA tests specific to Brucella;
- Development of an indirect ELISA using antigens specific to Yersinia;
- Development of immunoaffinity enrichment to improve direct bacteriological
isolation of Yersinia;
- Development of a polymerase chain reaction-gene probe detection system
specific for pathogenic strains of Yersinia;
- Experimental infection of cattle;
- Field trials.
Fields of science (EuroSciVoc)
- natural sciences biological sciences microbiology bacteriology
- agricultural sciences animal and dairy science domestic animals animal husbandry
- engineering and technology medical engineering medical laboratory technology laboratory samples analysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
94703 MAISONS-ALFORT CEDEX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.