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IMPROVED METHODS FOR THE DIAGNOSIS OF RUMINANT ALPHAHERPESVIRUS INFECTIONS IN RELATION TO THE CONTROL OF INFECTIOUS BOVINE RHINOTRACHEITIS (IBR)

Objective



Background :

Bovine herpesvirus 1 (BHV-1) infection in cattle is a disease of major economic concern in Europe, both in countries where this infection has been eradicated and in those where the control of infectious bovine rhinotracheitis (IBR) is currently or will be undertaken. Successful control of IBR depends on the use of efficient, sensitive and specific diagnostic tests. The efficiency of the existing diagnostic methods is compromised by the existence of serological cross-reactivity between BHV-1 and the other closely related alphaherpesviruses.

The objective is :

The aim of this research is 1) to assess the risk of cross-infection between BHV-1 and other alphaherpesviruses in ruminants, and 2) to develop diagnostic methods capable of differentiating the different ruminant alphaherpesviruses infections.

Short description of the project :

The work will be subdivided into 3 phases :

- in vivo evaluation of cross-infections of cattle
- serological differentiation of ruminant alphaaherpesviruses related to BHV-1
- genomic differentiation of ruminant alphaviruses related to BHV-1

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF LIEGE
Address
Bld. De Colonster, 20 - B 43 Bis
4000 Liege
Belgium

Participants (5)

MAFF Central Veterinary Laboratory
United Kingdom
Address
Woodham Lane New Haw Addlestone
KT15 3NB Weybridge
MOREDUN RESEARCH INSTITUTE
United Kingdom
Address
Bush Loan Pentlands Science Park
EH26 0PZ Penicuik
NATIONAL VETERINARY AND FOOD RESEARCH INSTITUTE
Finland
Address
Hämeentie, 57 - P.o. Box 368
00231 Helsinki
THE NATIONAL VETERINARY INSTITUTE
Sweden
Address
P.o. Box 585
751 23 Uppsala
UNIVERSITY OF ZURICH
Switzerland
Address
Winterthurerstrasse, 266 A
8057 Zürich