Bovine herpesvirus 1 (BHV-1) infection in cattle is a disease of major economic concern in Europe, both in countries where this infection has been eradicated and in those where the control of infectious bovine rhinotracheitis (IBR) is currently or will be undertaken. Successful control of IBR depends on the use of efficient, sensitive and specific diagnostic tests. The efficiency of the existing diagnostic methods is compromised by the existence of serological cross-reactivity between BHV-1 and the other closely related alphaherpesviruses.
The objective is :
The aim of this research is 1) to assess the risk of cross-infection between BHV-1 and other alphaherpesviruses in ruminants, and 2) to develop diagnostic methods capable of differentiating the different ruminant alphaherpesviruses infections.
Short description of the project :
The work will be subdivided into 3 phases :
- in vivo evaluation of cross-infections of cattle
- serological differentiation of ruminant alphaaherpesviruses related to BHV-1
- genomic differentiation of ruminant alphaviruses related to BHV-1
Funding SchemeCSC - Cost-sharing contracts
KT15 3NB Weybridge
EH26 0PZ Penicuik
751 23 Uppsala