Objective
ASF remains endemic in Sardinia as well as in large parts of Africa where it is currently growing in an explosive manner, posing a constant threat to European and worlwide pig farming.
To control new outbreaks of the disease, as well as for the surveillance of free areas, rapid and reliable diagnostic tests are crucial. One of the objectives of the Project is the development of more sensitive tests for ASFV antibody detection, based on the use of recombinant virus proteins. The correlation between new outbreaks and the possible source of the virus strain has been very difficult to establish.
A new approach to the molecular epidemiology of ASFV will be the characterization of virus isolates by DNA sequencing. The understanding of the pathogenesis of the disease will be another objective of this project. In acute ASF, alterations triggered by cytokines released by cells of the mononuclear phagocyte lineage, which are potent mediators of the inflammatory response, might contribute to the clinical symptoms observed. A determination of the cytokine profile in infected animals will provide information of the role that these bioactive factors play in the pathogenesis of severe form of the disease. In this context, the function of certain viral genes that might modulate the apoptosis of the infected cells will also be studied. The knowledge of the sequence of the ASFV genome will allow to design new strategies for the development of preventive tools for ASF. Thus, two viral genes encoding proteins that may be involved in the virus evasion of the host's immune response have been identified. An important objective will be to define the role of these genes in the infection. On the other hand, the molecular characterization of the cellular and viral components involved in the attachment and entry of the virus into the host cell may identify new targets for virus neutralization.
A study of the cellular immune response against ASFV infection will also be carried out, defining the role of T Iymphocyte subpopulations and the cytokines produced in ASFV-specific responses. Finally, the development of vectors carrying specific ASFV genes will be of great importance to accomplish the proposed objectives.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences public health epidemiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- agricultural sciences animal and dairy science domestic animals animal husbandry
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28049 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.