Short and long term effects of genetic immunization on the fish immune system

Project Information

Grant agreement ID: FAIR984026

Project closed

Start date 1 January 1999

End date 31 December 2001

Funded under

• Specific research, technological development and demonstration programme in the field of agriculture and fisheries (including agro-industry, food technologies, forestry, aquaculture and rural development), 1994-1998

Total cost € 556 000,00

EU contribution € 556 000,00

Coordinated by

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France

Objective

Using the rainbow trout (RBT) and viral haemorrhagic septicaemia virus ( VHSV) genes as a model of immunization, the aims of the present project are

i) to analyse the effects of a long lasting antigen production on the specific and non specific immune response,
ii) to analyse the effect of the continuous delivery of the antigen on the shape of the B and T cell repertoires,
iii) to evaluate the modulating potential of selected cytokine or virus-induced genes on the immune response to genetic immunization

Nucleic acid immunization can induce antibodies, cytotoxic T lymphocytes (CTL) and protection against many pathogens. The underlying mechanisms remain obscure and must be understood to permit rational manipulation and optimisation of the methodology.

Fields of science

Not validated

• natural sciences › biological sciences › biochemistry › biomolecules › nucleic acids
• medical and health sciences › basic medicine › immunology › immunisation
• natural sciences › biological sciences › microbiology › virology

Programme(s)

• FP4-FAIR - Specific research, technological development and demonstration programme in the field of agriculture and fisheries (including agro-industry, food technologies, forestry, aquaculture and rural development), 1994-1998

Topic(s)

• 5.3.2 - Health of aquacultured species

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

• EU contribution: No data
• Address: Domaine de Vilvert ; 78352 JOUY-EN-JOSAS ; France
• Total cost: No data

Participants (2)

University of Aberdeen

United Kingdom

• EU contribution: No data
• Address: 2 Tillydrone Avenue ; AB9 2TN Aberdeen
• Total cost: No data

Uppsala University

Sweden

• EU contribution: No data
• Address: 751 24 Uppsala
• Total cost: No data