Objective
Using the rainbow trout (RBT) and viral haemorrhagic septicaemia virus ( VHSV) genes as a model of immunization, the aims of the present project are
i) to analyse the effects of a long lasting antigen production on the specific and non specific immune response,
ii) to analyse the effect of the continuous delivery of the antigen on the shape of the B and T cell repertoires,
iii) to evaluate the modulating potential of selected cytokine or virus-induced genes on the immune response to genetic immunization
Nucleic acid immunization can induce antibodies, cytotoxic T lymphocytes (CTL) and protection against many pathogens. The underlying mechanisms remain obscure and must be understood to permit rational manipulation and optimisation of the methodology.
Fields of science
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
78352 JOUY-EN-JOSAS
France