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Short and long term effects of genetic immunization on the fish immune system

Objective

Using the rainbow trout (RBT) and viral haemorrhagic septicaemia virus ( VHSV) genes as a model of immunization, the aims of the present project are

i) to analyse the effects of a long lasting antigen production on the specific and non specific immune response,
ii) to analyse the effect of the continuous delivery of the antigen on the shape of the B and T cell repertoires,
iii) to evaluate the modulating potential of selected cytokine or virus-induced genes on the immune response to genetic immunization

Nucleic acid immunization can induce antibodies, cytotoxic T lymphocytes (CTL) and protection against many pathogens. The underlying mechanisms remain obscure and must be understood to permit rational manipulation and optimisation of the methodology.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Address
Domaine De Vilvert
78352 Jouy-en-josas
France

Participants (2)

University of Aberdeen
United Kingdom
Address
2 Tillydrone Avenue
AB9 2TN Aberdeen
Uppsala University
Sweden
Address

751 24 Uppsala