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Short and long term effects of genetic immunization on the fish immune system

Objective

Using the rainbow trout (RBT) and viral haemorrhagic septicaemia virus ( VHSV) genes as a model of immunization, the aims of the present project are

i) to analyse the effects of a long lasting antigen production on the specific and non specific immune response,
ii) to analyse the effect of the continuous delivery of the antigen on the shape of the B and T cell repertoires,
iii) to evaluate the modulating potential of selected cytokine or virus-induced genes on the immune response to genetic immunization

Nucleic acid immunization can induce antibodies, cytotoxic T lymphocytes (CTL) and protection against many pathogens. The underlying mechanisms remain obscure and must be understood to permit rational manipulation and optimisation of the methodology.

Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Address
Domaine De Vilvert
78352 Jouy-en-josas
France

Participants (2)

University of Aberdeen
United Kingdom
Address
2 Tillydrone Avenue
AB9 2TN Aberdeen
Uppsala University
Sweden
Address

751 24 Uppsala