Using the rainbow trout (RBT) and viral haemorrhagic septicaemia virus ( VHSV) genes as a model of immunization, the aims of the present project are
i) to analyse the effects of a long lasting antigen production on the specific and non specific immune response,
ii) to analyse the effect of the continuous delivery of the antigen on the shape of the B and T cell repertoires,
iii) to evaluate the modulating potential of selected cytokine or virus-induced genes on the immune response to genetic immunization
Nucleic acid immunization can induce antibodies, cytotoxic T lymphocytes (CTL) and protection against many pathogens. The underlying mechanisms remain obscure and must be understood to permit rational manipulation and optimisation of the methodology.
Funding SchemeCSC - Cost-sharing contracts
AB9 2TN Aberdeen
751 24 Uppsala