Genetics of radiation induced cancer: identification and mapping of germline and somatic mutations determining predisposition

Objective

The project directly responds to the call to identify genes determining individual susceptibility to radiation-induced cancer. The experimental goals are to map and subsequently identify these genes. The benefits of this study will be the provision of individual risk assessments through genetic analysis, and a greater understanding of the biology of radiation carcinogenesis. The participants will conduct a series of animal experiments using the molecular genetic techniques of quantitative trait locus (QTL) mapping and loss of heterozygosity (LOH) analysis. Susceptibility to five common radiogenic tumour types affecting bone, gut, mammary, lung and lymphopoietic tissues will be studied. Through sharing of data with other consortia it is anticipated that a comprehensive set of genes determining susceptibility can be identified.

Programme(s)

• FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002)

Topic(s)

• 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH

Address

Ingolstädter Landstrasse 1
85764 Neuherberg Bei München
Germany

Participants (4)

COMMISSARIAT A L'ENERGIE ATOMIQUE

France

Address

Avenue Du General Leclerc 60-68
92265 Fontenay Aux Roses

NATIONAL RADIOLOGICAL PROTECTION BOARD

United Kingdom

Address

OX11 0RQ Didcot,harwell,chilton

TECHNICAL UNIVERSITY OF MUNICH

Germany

Address

Ismaningerstrasse 22
81675 Muenchen

UNIVERSITY OF GLASGOW

United Kingdom

Address

University Avenue
G12 8QQ Glasgow