Objective The project directly responds to the call to identify genes determining individual susceptibility to radiation-induced cancer. The experimental goals are to map and subsequently identify these genes. The benefits of this study will be the provision of individual risk assessments through genetic analysis, and a greater understanding of the biology of radiation carcinogenesis. The participants will conduct a series of animal experiments using the molecular genetic techniques of quantitative trait locus (QTL) mapping and loss of heterozygosity (LOH) analysis. Susceptibility to five common radiogenic tumour types affecting bone, gut, mammary, lung and lymphopoietic tissues will be studied. Through sharing of data with other consortia it is anticipated that a comprehensive set of genes determining susceptibility can be identified. Fields of science natural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineoncology Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Topic(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH EU contribution No data Address Ingolstädter Landstrasse 1 85764 Neuherberg bei München Germany See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution No data Address Avenue du General Leclerc 60-68 92265 FONTENAY AUX ROSES See on map Total cost No data NATIONAL RADIOLOGICAL PROTECTION BOARD United Kingdom EU contribution No data Address OX11 0RQ DIDCOT,HARWELL,CHILTON See on map Total cost No data TECHNICAL UNIVERSITY OF MUNICH Germany EU contribution No data Address Ismaningerstrasse 22 81675 MUENCHEN See on map Total cost No data UNIVERSITY OF GLASGOW United Kingdom EU contribution No data Address University Avenue G12 8QQ Glasgow See on map Total cost No data
