Quantification of lung cancer risk after low radon exposure and low exposure rate: synthesis from epidemiologic and experimental data

Objective

Occupational exposure to radon in European uranium mines during the last 30 years was at low annual rate; follow-up of 10 000 miners over more than 20 years made it possible to organise a joint analysis. This joint study has a good statistical power, able to detect lom lung cancer risks linked to low annual exposure; modifying factors like attained age, dose-rate, and concomitant exposures (gamma, ore dust) will be studied in this large cohort. Nested case-control studies will be implemented in order to test the radon-tobacco interaction. Domestic radon plus occupational exposure will be studied in one of the case-control studies. Animal experiments will be continued. Mechanistic modelling will be applied to both animal and human data.

Fields of science

• natural sciences › chemical sciences › inorganic chemistry › noble gases
• medical and health sciences › clinical medicine › oncology › lung cancer

Programme(s)

• FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002)

Topic(s)

• 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE

Address

Rue Auguste Lemaire
92262 Fontenay Aux Roses
France

Links

Participants (7)

AEA TECHNOLOGY PLC

United Kingdom

Address

Harwell 551
OX11 0RA Didcot,harwell,chilton

Links

BUNDESAMT FUER STRAHLENSCHUTZ

Germany

Address

1,ingolstädter Landstraße 1
85764 Oberschleissheim

Links

COMMISSARIAT A L'ENERGIE ATOMIQUE

France

Address

Avenue Du General Leclerc 60-68
92265 Fontenay Aux Roses

Links

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH

Germany

Address

Ingolstaedter Landstrasse 1
85764 Oberschleissheim

Links

NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT

Netherlands

Address

Anthonie Van Leuwenhoeklaan 9
3720 BA Bilthoven

Links

NATIONAL RADIATION PROTECTION INSTITUTE

Czechia

Address

Srobarova 48
100 00 Praha 10

Links

National Radiological Protection Board (NRPB)

United Kingdom

Address

Chilton
OX11 0RQ Didcot

Links