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Quantification of lung cancer risk after low radon exposure and low exposure rate: synthesis from epidemiologic and experimental data

Objective

Occupational exposure to radon in European uranium mines during the last 30 years was at low annual rate; follow-up of 10 000 miners over more than 20 years made it possible to organise a joint analysis. This joint study has a good statistical power, able to detect lom lung cancer risks linked to low annual exposure; modifying factors like attained age, dose-rate, and concomitant exposures (gamma, ore dust) will be studied in this large cohort. Nested case-control studies will be implemented in order to test the radon-tobacco interaction. Domestic radon plus occupational exposure will be studied in one of the case-control studies. Animal experiments will be continued. Mechanistic modelling will be applied to both animal and human data.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
Address
Rue Auguste Lemaire
92262 Fontenay Aux Roses
France

Participants (7)

AEA TECHNOLOGY PLC
United Kingdom
Address
Harwell 551
OX11 0RA Didcot,harwell,chilton
BUNDESAMT FUER STRAHLENSCHUTZ
Germany
Address
1,Ingolstädter Landstraße 1
85764 Oberschleissheim
COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
Avenue Du General Leclerc 60-68
92265 Fontenay Aux Roses
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstrasse 1
85764 Oberschleissheim
NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT
Netherlands
Address
Anthonie Van Leuwenhoeklaan 9
3720 BA Bilthoven
NATIONAL RADIATION PROTECTION INSTITUTE
Czechia
Address
Srobarova 48
100 00 Praha 10
National Radiological Protection Board (NRPB)
United Kingdom
Address
Chilton
OX11 0RQ Didcot