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Novel approaches in the management of the radiation injury

Objective

The proposal constitutes a novel and multidisciplinary approach for improving the management of the radiation injury. The study firstly aims to develop new indicators for predicting the radiation injury produced in the hematopoietic and the epithelial tissues. This will be addressed by studying the total hematopoietic stem cell reserve that survives after irradiation, and by conducting large screenings of gene expression in irradiated human skin. The proposal also aims to improve the understanding of the damage produced by radiation in critical tissues. New model s aiming to define the radiation response of the different human hematopoietic stem cells are proposed. In addition, the eosinophilia, fibrosis and keratosis reactions produced during the cutaneous radiation syndrome will be investigated. Finally, new alternatives for ameliorating the hematopoietic aplasia, for preventing the inflammatory reaction and for treating the cutaneous radiation syndrome are proposed.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIAMBIENTALES Y TECNOLOGICAS
Address
Avenida Complutense 22
28040 Madrid
Spain

Participants (5)

COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
Rue Gaston Cremieux 2
91057 Evry
ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
Address
50,Dr. Molewaterplein 50
3000 DR Rotterdam
INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
France
Address
Rue Auguste Lemaire
92262 Fontenay Aux Roses
STIFTUNG FUER LASERTECHNOLOGIEN IN DER MEDIZIN UND MESSTECHNIK AN DER UNIVERSITAET ULM
Germany
Address
Helmholzstrasse 12
89081 Ulm
UNIVERSITY OF ULM
Germany
Address
40,Albert-einstein-allee 11
89081 Ulm