The proposal constitutes a novel and multidisciplinary approach for improving the management of the radiation injury. The study firstly aims to develop new indicators for predicting the radiation injury produced in the hematopoietic and the epithelial tissues. This will be addressed by studying the total hematopoietic stem cell reserve that survives after irradiation, and by conducting large screenings of gene expression in irradiated human skin. The proposal also aims to improve the understanding of the damage produced by radiation in critical tissues. New model s aiming to define the radiation response of the different human hematopoietic stem cells are proposed. In addition, the eosinophilia, fibrosis and keratosis reactions produced during the cutaneous radiation syndrome will be investigated. Finally, new alternatives for ameliorating the hematopoietic aplasia, for preventing the inflammatory reaction and for treating the cutaneous radiation syndrome are proposed.
Funding SchemeCSC - Cost-sharing contracts
3000 DR Rotterdam
92262 Fontenay Aux Roses