Objective Recent reports in the mouse indicate considerable radiation sensitivity of particularly the early zygote and the post implantation gastrula stages. Data on the chromatin stability of human sperm and chromosome stability of pre implantation embryos point at the genetic vulnerability of these stages in our species. We propose to assess, for the mouse, the roles of single and double strand DNA break repair and cell cycle control at the zygote and gastrula stages in response to radiation-caused DNA damage of male post meiotic haplophase stages, the zygote- and gastrula stages. Various genetic, cell cycle and developmental endpoints will be utilised to understand the importance of DNA break repair and cell cycle control for the transmission of genetic damage for sperm, zygote and gastrula stages, such that risk assessment and mechanistic insight are coupled. By including transcriptome analysis, DNA damage response genes can be identified. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticschromosomesmedical and health sciencesclinical medicineembryology Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Topic(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator CATHOLIC UNIVERSITY OF NIJMEGEN EU contribution No data Address Geert Grooteplein 29 6500 HB NIJMEGEN Netherlands See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all BELGIAN NUCLEAR RESEARCH CENTRE Belgium EU contribution No data Address 200,Boeretang 200 2400 MOL See on map Total cost No data ITALIAN AGENCY FOR NEW TECHNOLOGY, ENERGY AND THE ENVIRONMENT Italy EU contribution No data Address Via Anguillarese 301 00060 ROMA See on map Total cost No data LEIDEN UNIVERSITY Netherlands EU contribution No data Address Wassenaarseweg 72 2300 RA LEIDEN See on map Total cost No data UNIVERSITY OF LEICESTER United Kingdom EU contribution No data Address University Road LE1 7RH LEICESTER See on map Total cost No data
