Telomeres and radiosensitivity of individuals

Objective

Risk estimate of radiation-induced cancer in human population is based on epidemiological data. Most extrapolations are limited by the lack of understanding of the mechanisms responsible for radiation carcinogenesis. The acquisition of knowledge on common genetic factors that might determine inter-individual differences in low dose cancer risk encounters similar limitations. During TELORAD Project, evidence is accumulating that telomeres may be involved in cellular and organismal responsesto IR. Mice lacking functional telomerase are radiosensitive. Ataxia telangiectasia, Fanconia patients are radiosensitive and show altered telomere maintenance. The major aim of TELOSENS consortiumis to work on a goal oriented project to be able to give a precise answer to the following question :ISTELOMERE HETEROGENEITY A PARAMETER OF INDIVIDUAL RADIOSENSITIVITY for short term effect?

Programme(s)

• FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002)

Topic(s)

• 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

COMMISSARIAT A L'ENERGIE ATOMIQUE

Address

Ctr Etudes Fontenay-aux-roses Ce-far
92265 Fontenay Aux Roses
France

Participants (10)

AUTONOMOUS UNIVERSITY OF BARCELONA

Spain

Address

Campus De Bellaterra Edifici M
08193 Bellaterra

BRUNEL UNIVERSITY

United Kingdom

Address

Kingston Lane
UB8 3HP Uxbridge

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Allée D'italie 46
69364 Lyon

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

Campus De La Universidad Autonoma De Madrid
28049 Madrid

ECOLE NORMALE SUPERIEURE DE LYON

France

Address

46,Allée D'italie 46
69364 Lyon

NATIONAL RESEARCH COUNCIL OF ITALY

Italy

Address

Via Abbiategrasso, 207
27100 Pavia

SERVICIO GALEGO DE SAUDE - SERGAS

Spain

Address

Xubias De Arriba, 84
15006 La Coruna

UNIVERSITA DEGLI STUDI DI PAVIA

Italy

Address

Via Ferrata 1
27100 Pavia

UNIVERSITY OF AARHUS

Denmark

Address

Universitets-parken Batholing Building
8000 Aarhus C

UNIVERSITY OF ESSEN

Germany

Address

Hufelandstrasse 55
45147 Essen