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Telomeres and radiosensitivity of individuals

Objective

Risk estimate of radiation-induced cancer in human population is based on epidemiological data. Most extrapolations are limited by the lack of understanding of the mechanisms responsible for radiation carcinogenesis. The acquisition of knowledge on common genetic factors that might determine inter-individual differences in low dose cancer risk encounters similar limitations. During TELORAD Project, evidence is accumulating that telomeres may be involved in cellular and organismal responsesto IR. Mice lacking functional telomerase are radiosensitive. Ataxia telangiectasia, Fanconia patients are radiosensitive and show altered telomere maintenance. The major aim of TELOSENS consortiumis to work on a goal oriented project to be able to give a precise answer to the following question :ISTELOMERE HETEROGENEITY A PARAMETER OF INDIVIDUAL RADIOSENSITIVITY for short term effect?

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

COMMISSARIAT A L'ENERGIE ATOMIQUE
Address
Ctr Etudes Fontenay-aux-roses Ce-far
92265 Fontenay Aux Roses
France

Participants (10)

AUTONOMOUS UNIVERSITY OF BARCELONA
Spain
Address
Campus De Bellaterra Edifici M
08193 Bellaterra
BRUNEL UNIVERSITY
United Kingdom
Address
Kingston Lane
UB8 3HP Uxbridge
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Allée D'italie 46
69364 Lyon
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Campus De La Universidad Autonoma De Madrid
28049 Madrid
ECOLE NORMALE SUPERIEURE DE LYON
France
Address
46,Allée D'italie 46
69364 Lyon
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Via Abbiategrasso, 207
27100 Pavia
SERVICIO GALEGO DE SAUDE - SERGAS
Spain
Address
Xubias De Arriba, 84
15006 La Coruna
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
Address
Via Ferrata 1
27100 Pavia
UNIVERSITY OF AARHUS
Denmark
Address
Universitets-parken Batholing Building
8000 Aarhus C
UNIVERSITY OF ESSEN
Germany
Address
Hufelandstrasse 55
45147 Essen