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Risk estimation for ionizing radiation using mechanistic cancer modelling


The main objective is risk analysis for low doses of ionising radiation using a biologically based cancer model. Important aspects are: the form of the dose-effect relationship at very low doses and the question whether it is linear, linear-quadratic or whether there is a threshold. The ultimate aim is the derivation of improved estimates of radiation risks for radiological protection.
The main task for the applicant will be to continue working with the two-mutation carcinogenesis (TMC) model, to advance the model and make it applicable for other data sets and cancer in other organs, to use suitable animal data to investigate mechanistic aspects of radiological effects and to investigate suitable epidemiological data for description and model testing.
The proposed research allows to consider and possibly implement new concepts such as an induction of cellular defence mechanisms and bystander effects. These important radiobiological phenomena could be included and tested within the framework of the TMC model.
The applicant works in the field of low dose research since more than 8 years and is currently involved with the EU project CEC .Contract FIGH-CT-1999-00005. His range of knowledge and expertise in the field of the proposed research is interesting to be incorporated into the TMC model.

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9,antonie van leeuwenhoeklaan 9
3720 BA Bilthoven

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