Objective
Mammalian L-amino acid decarboxylases producing 1,4-diamines: histidine decarboxylase (HDC), aromatic L-amino acid decarboxylase (DDC) and ornithine decarboxylase (ODC); and their products: histamine, serotonin, tryptamine and putrescine, exhibit functional, metabolic and enzymic properties in common. HDC has been related to very different topics: alergy, neurochemistry and cell proliferation, as also described for DD and ODC. The Host Group have detected some analogies among the deduced primary sequences of these proteins. The common protein motifs observed every mammalian L-amino acid decarboxylase could be involved in the rapid turnover of these enzymes and/or in the decarboxylation mechanisms. In order to check this hypothesis, we will study the post-translational modifications and activities of expressed recombinant cDNAs encoding the rat mature HDC subunit and directed mutant DNA sequences. The characterization of the molecular underlying mechanisms of L-amino acid decarboxylase turnover and catalysis mechanisms will provide important basis for therapeutic strategies in alergy, neurochemistry and cell proliferation fields.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
29071 Málaga
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.