Objective
The linear sequence of amino acids in a small protein is sufficient to code for its folding into its functional tertiary structure. However, scientists have not yet managed to unscramble this code, and as a consequence the folded structure of a protein cannot be predicted from its known sequence of amino acids. The cracking of this code is therefore one of the great challenges of contemporary science and is the subject of much current research activity.
We plan to make a contribution to the solution of this problem by studying the foldings of the proteins ubiquitin and ferredoxin. The former is a protein which is found in every cell, and is physiologically important in the destruction of defective proteins. The latter is involved in the process of photosynthesis.
Both the chosen proteins are believed to be excellent models because as proteins go, they are relatively small and simple. The N-terminus of each of these proteins is involved in the formation of a loop structure, which is commonly described as a B-hairpin. These hairpin loops, each of about 17 amino acids, are to be synthesised by solid phase peptide synthesis, and the technique of proton nuclear magnetic resonance then used to determine if these fragments of the whole proteins take up structures analogous to those found in the proteins themselves.
Synthesis of modified hairpins, will allow us to probe those features which are important in the determination of loop structures.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins protein folding
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences botany
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1EW Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.