Objective
Allogeneic bone marrow transplantation for the treatment of leukemia in patients with acute lymphocytic leukemia (ALL) is used with increasing frequency. However, one of the major shortcomings remains the risk of leukemic relapse. In ALL of mature T-cells (T-ALL) the variable region of the T-cell receptor (VB) is unique for all monoclonal tumor cells, thus representing a 'tumor defining antigen'. In order to induce a graft-versus-leukemia reaction directed specifically against these tumor cells, HLA-matched, CD8+ T-cells will be primed in vitro by autologous dendritic cells presenting recombinant VB tumor antigen. In vitro primed cytotoxic CD8+ T-cells will subsequently be tested for their ability to specifically kill the T-ALL cells from which the recombinant VB was derived. If so, this in vitro model would open new avenues in the protection from leukemic relapse of T-ALL patients after allogeneic bone marrow transplantation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine oncology leukemia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
79106 Freiburg
Germany
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